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AN ANALYSIS OF MYCOBACTERIUM LEPRAE EPITOPE IMPRINTING UTILISING THE NANO-MIP TECHNOLOGY AND A MULTIPLE MONOMER APPROACH

ABSTRACT

Early diagnosis is usually preferable, but it offers commendable advantages for chronic infectious diseases. Many illnesses remain untreated until they reach an incurable and lethal stage, despite the mass healthcare industry’s impressive efforts in their various R&D sectors. According to a February 10, 2019, article in the newspaper "The Hindu," 90,709 leprosy cases were registered in 2017–18. By 2020, WHO wants to see no children with leprosy or abnormalities. After 2005, when the incidence rate was 0.84%, leprosy was proclaimed eradicated in India; nevertheless, in 2011, it was discovered that the illness was still very much present. Human leprosy is induced by the obligate intracellular infection Mycobacterium leprae. The patient’s immunological state both during the initial infection and during the disease’s progression determines the clinical presentation and histopathologic alterations (Britton and Lockwood 2004). Finding at least one of the accompanying cardinal indications that the World Health Organisation (WHO) has researched (WHO 2006) is how leprosy is diagnosed. 1. A noticeable lack of feeling in a region of pale (hypopigmented) or reddish skin, 2. A peripheral nerve that is swollen or enlarged, resulting in weakening and/or lack of feeling in the muscles it supplies, 3. A split skin smear containing acid-fast bacilli.

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