Issue Details
SYNTHESIS OF SOME NEW THIAZOLYL CHROMENONE DERIVATIVES BY USING α,α- DIBROMOKETONES
Pooja, Monika Chahar, Parul, Vijay Kiran, Jasbir Sangwan
Page No. : 65-75
ABSTRACT
In organic synthesis, Thiosemicarbazide becomes one of the finest approach for the preparation of various heterocyclic compounds. Those reactions which contains C=O and C=N categories with thiosemicarbazide results in the composition of bioactive compounds specifically thiazoles. Hydrazine fragment contains a internal nitrogen centre which is the most softer nucleophilic centre as compared to effective absolute nitrogen, promotors allowing to nucleophillic replacement by the powerful nitrogen experienced cyclisation reaction to provide excellent yield of heterocycles under mild conditions. In the current study, some new derivatives of coumarin turned out to be formulated by treating “3-acetyl-2H-chromen-2-one” with hydrazinecarbothioamide subsequently cyclize with ethyl acetoacetate and then proceed with α,α- dibromoketones with the help of Hantzsch thiazole synthesis and to prepare other compounds and their pharmaceutical importance. All the compounds were identified by spectral details and physical evidence.
FULL TEXT
