Issue Details
SYNTHESIS OF SOME NEW THIAZOLE DERIVATIVES WITH THE HELP OF HYDROXY(TOSYLOXY)IODOBENZENE
Ms. Parul, Monika Chahar, Vijay Kiran, Pooja, Jasbir Sangwan
Page No. : 67-72
ABSTRACT
As we all know, succinimide and thiosemicarbazide are commercially available reagents. Firstly, we synthesised succinimide and thiosemicarbazide in the presence of ethanol. We synthesised it on stirring, but we did not get any product. Then we transfer the same reaction mixture on reflux conditions in the presence of the catalytic amount of glacial acetic acid, and we got a new synthesised of 2,2’(pyrrolidine-2,5-diylidine)bis(hydrazine-1-carbothioamide. The synthesised reactant was characterised by 1H,13C, and Mass spectroscopy. Further, the synthesised reactant was treated with substituted tosylates, and new and facile products of thiazoles were formed. The synthesised products were confirmed through spectral data. With the help of Hantzch, thiazole was treated with HTIB, and we got thiazoles. Further, we are interested in their biological activities, which give its pharmacological importance synthesis, the prepared hydrazine-1-carbothioamide derivatives.
FULL TEXT
