Issue Details
α,α- DIBROMOKETONES IN THE PREPARATION OF NEW HYDRAZINYL THIAZOLE DERIVATIVES
Ms. Parul, Monika Chahar, Vijay Kiran, Pooja, Jasbir Sangwan
Page No. : 30-37
ABSTRACT
In medicative applications, succinimides are acknowledged heterocyclic compounds in drug invention which give rise to multiple remedially linked practices in pharmaceutical world. Both succinimide and thiosemicarbazide are vigorous intermediates for the fusion of pharmaceutic and biologically active matter and consequently these are utilized enormously in the discipline of medicinal chemistry. Various researchers and scientists have recognized and incorporated various derivatives of succinimide with numerous therapeutic belongings. Concurrently, SAR examination has been moderately acquired beside with a substantial concern of derivatives had been obtained for possible objective. In present paper, various derivatives of succinimide eventually be prepared by the analysis of succinimide with hydrazinecarbothioamide in ethanol under reflux condition and subsequently the resultant product was treated with various substituted α,α- dibromoketone by means of HTS (hantzsch thiazole synthesis) to coordinate further compounds and their structures were established by spectral studies and physical indications.
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