TECHNOLOGIES AND POLYMERS USED THROUGHOUT THE IMPROVEMENT OF THE DISSOLUTION RATE OF LOW SOLUBILIZATION DRUGS

ABSTRACT

In laboratories, this approach is the most often used method for evaluating the soluble of any substance at a given concentration. An abundance of the compound is disintegrated in a specific medium that is filled into vials and allowed to shake for a stated amount of time at a selected set of ambient temperature, until balance is attained. After specified intervals, the solubility compound is removed from the supernatant and the amount dissolved is decided using validated analyzes like thermal analysis, HPLC, or specttrophometric methods, among others. As a consequence of using this procedure, many pairs of vials are put, but then when two pairs of vials provide the same result at the same time, it may be considered that balance has been attained. This approach is the best appropriate for calculating Equilibrium solubility in a solution. The approaches simplicity and ease of use are two of its major benefits. This approach has a number of drawbacks, including a shortage of sensitive analytical processes during the early phases of drug development, as well as the fact that measuring solubility by this technique requires a timeframe of 24 or 48 hours, or it may even take one week in certain cases.

FULL TEXT